Missionary nuns, Sisters Ruth and Naomi, travel to St. Timothy's to carry out God's work when the mission becomes overrun by Red Dog and the Hunters, a band of renegade Comanche Indians. Arn Walker, a track and guide gunman, offers the nuns protection. Assembling the West's finest experts – Eb Tyler, a cowboy-turned-gunman, Mac Gibbs, an ex-Buffalo Soldier sergeant, and later Luke Brady, a drifter - they devise a plan of escape. But the outlaws set their sights on the two sisters, believing they hold the key to a vast fortune. It's gonna be a helluva ride!